Personally I've found closing the tab and opening a new one helps - so this is a minimal extension that does just that. It's my first extension, and only a few lines of code... it works for me, and I hope it works for others.
You can find the extension on the Chrome Web Store
The icon used is courtesy of newmoon's handywork athttp://code.google.com/p/ultimate-gnome/
The new version (1.1) of the extension includes an option (disabled by default) to catch the Ctrl-F5 keystroke and override the browser's builtin behaviour, but please note that when first installed, even if this option is enabled, it will not catch the keystroke on tabs that are already open until the page is otherwise refreshed... but any new pages will behave as required.
If it doesn't work how you'd expect, then you can contact me as meercat on gmail, or add a comment below. It would help if you could briefly describe
- whether you're using the toolbar button or the keystroke to invoke the extension
- what version of chrome you're running (and platform)
- what version of the extension you're using
- how I can contact you !!